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KMID : 0359819950240060623
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Journal of Korean Neurosurgical Society
1995 Volume.24 No. 6 p.623 ~ p.630
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Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery
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Abstract
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This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction. which then recovered to the basal tension of a
3-5
min.
later. and the reoxygenation that follows produced the biphasic (relaxation-contraction) response in the intact endothelial rings under resting tension,. The anoxia-induced contraction was potentiated by pretreatment with KCl and PGF2α.
Reoxygenation
produced only sustained relaxation. Removal of the endothelium and pretreatment with nimodipine or indomethacine markedly attenuated the anoxia-induced contractions. Anoxia transiently and significantly increased cyclic GMP contents in the
endothelium-intact preparations. but did not affect them in the endothelium-removed ones.
The above results suggest that anoxia-induced contraction is endothelium-dependent and is resultant to the release of a Prostaglandin-like substance(s).
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